Bottom Up? Middle Down? Any Which Way to Characterize Histone PTMs

Histone proteins, key components of chromatin, exhibit some interesting regulatory features involving the N-terminal tail. Sidoli et al. (2015) looked at how researchers examine these features proteomically, comparing middle-down proteomics with bottom-up preparation.1 Post-translational modifications (PTMs) of histone protein N-terminal regions constitute a regulatory feature that controls cell nuclear events such as gene expression and DNA repair. Read the rest of this article

The post Bottom Up? Middle Down? Any Which Way to Characterize Histone PTMs appeared first on Accelerating Science.

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