Histone proteins, key components of chromatin, exhibit some interesting regulatory features involving the N-terminal tail. Sidoli et al. (2015) looked at how researchers examine these features proteomically, comparing middle-down proteomics with bottom-up preparation.1 Post-translational modifications (PTMs) of histone protein N-terminal regions constitute a regulatory feature that controls cell nuclear events such as gene expression and DNA repair. Read the rest of this article
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